Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine)
1-Hydroxyethoxyethylpiperazine
CAS: 13349-82-1
Molecular Formula: C8H18N2O2
Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine) - Names and Identifiers
Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine) - Physico-chemical Properties
| Molecular Formula | C8H18N2O2 |
| Molar Mass | 174.24 |
| Density | 1.061g/mLat 25°C(lit.) |
| Boling Point | 112-114°C0.25mm Hg(lit.) |
| Flash Point | >230°F |
| Solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 7.57E-05mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.061 |
| Color | Clear colorless to yellow-brownish |
| pKa | 14.41±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | n20/D 1.497(lit.) |
| Physical and Chemical Properties | Boiling point 112-114 ℃(33Pa), relative density of 1.061. |
| Use | Used as a pharmaceutical Intermediate |
Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Class | IRRITANT |
Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine) - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Use | an intermediate of hydroxyzine, a weak neuroleptic. used as pharmaceutical intermediates organic synthesis, pharmaceutical synthesis intermediates, can be used for the synthesis of hydroxyzine hydrochloride raw material (2192-20-3). |
| production method | is obtained from the condensation of piperazine with chloroethoxyethanol. Piperazine hexahydrate and piperazine dihydrochloride were added to the reaction pot, heated to 140 °c with stirring, and distilled to obtain piperazine hydrochloride. It was cooled to 120 °c and chloroethoxyethanol was added dropwise. After completion of the addition, the temperature was raised to 150-155 ° C., the reaction was carried out for 4H, and the mixture was put into cold ethanol while hot, and cooled to 0-5 ° C. Filtering, filtrate plus sodium hydroxide solution neutralization, filtering sodium chloride, distilled ethanol, to obtain the finished product. The yield was 60%. |
Last Update：2024-04-09 20:49:11
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View History
Quetiapine IMpurity (1-[2-(2-Hydroxyethoxy)ethyl]piperazine)
NSC355364
3'-甲基-[1,1'-联苯]-4-胺
2',3'-O-异丙亚基鸟苷
磺胺间甲氧嘧啶标准品
ZVSMJEBFSMHOPE-UHFFFAOYSA-N
8-羟基-9,10-二异丁酰氧基麝香草酚
Pyrimidine, 2-chloro-4-ethynyl- (9CI)
[2H5]-乙基硫酸钠
硫杂环丁烷-3-醇
NSC355364
3'-甲基-[1,1'-联苯]-4-胺
2',3'-O-异丙亚基鸟苷
磺胺间甲氧嘧啶标准品
ZVSMJEBFSMHOPE-UHFFFAOYSA-N
8-羟基-9,10-二异丁酰氧基麝香草酚
Pyrimidine, 2-chloro-4-ethynyl- (9CI)
[2H5]-乙基硫酸钠
硫杂环丁烷-3-醇